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RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division, Nat Cell Biol, 23 Mar 2020

发布时间: 2020年03月23日

Nature Cell Biology, 23 March, 2020, DOI:

RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division

jicheng zhao, min wang, luyuan chang, juan yu, aoqun song, cuifang liu, wenjun huang, tiantian zhang, xudong wu, xiaohua shen, bing zhu & guohong li

Abstract

stable propagation of epigenetic information is important for maintaining cell identity in multicellular organisms. however, it remains largely unknown how mono-ubiquitinated histone h2a on lysine 119 (h2ak119ub1) is established and stably propagated during cell division. in this study, we found that the proteins rybp and yaf2 each specifically bind h2ak119ub1 to recruit the rybp–prc1 or yaf2–prc1 complex to catalyse the ubiquitination of h2a on neighbouring nucleosomes through a positive-feedback model. additionally, we demonstrated that histone h1-compacted chromatin enhances the distal propagation of h2ak119ub1, thereby reinforcing the inheritance of h2ak119ub1 during cell division. moreover, we showed that either disruption of rybp/yaf2–prc1 activity or impairment of histone h1-dependent chromatin compaction resulted in a significant defect of the maintenance of h2ak119ub1. therefore, our results suggest that histone h1-dependent chromatin compaction plays a critical role in the stable propagation of h2ak119ub1 by rybp/yaf2–prc1 during cell division.

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